Meyerhoff Graduate Fellows Program

Student Profiles

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Afsoon Saadin
Biological Sciences

Area of Doctoral Study: Molecular and Cell Biology

Undergraduate Institution: Azad University-Iran

Other Graduate Institute: UMBC (M.S. in Applied Molecular Biology)

Research Advisor: Michelle Starz-Gaiano, Ph.D.

Description of Research

Cell migration, which is required for various desired biological events, is also the cause of an undesired phenomenon, tumor metastasis. Out of different signaling pathways that contribute to cell migration, the Janus Kinase/Signal Inducer and Activator of Transcription (JAK/STAT) is of high interest since this pathway is involved in various biological processes and dysfunction of the pathway is correlated to different human diseases, including immune disorders and tumorigenesis. Some components of this pathway including DOME, UNPAIRED, JAK and STAT are well characterized, however, other components of the pathway including APT and SOCS are not completely understood. It has been shown that both APT and SOCS affect cell migration but the mechanism by which they act is not clear. We propose to understand better the global role of APT and the mechanism by which it functions.

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